In 1996, a reunion Wiseguy movie starring Ken Wahl aired on ABC. In the movie, Vinnie (who was still alive; as far as this movie was concerned, the fourth season had never happened) had spent several years on wiretapping duty, as punishment for being Aiuppo's dupe during Season 3's Mafia angle, and (presumably) abandoning his duty during the Volchek investigation. Vinnie is ordered to infiltrate the organization of criminal boss Paul Callendar (Ted Levine). The movie had many of the same themes as the TV show, including Vinnie's constant conflict in betraying the people he had grown to care about. While the movie was a critical success, its mediocre ratings (it aired against NBC megahits Friends and Seinfeld) and Ken Wahl's recurrent back and neck problems seem to preclude another Wiseguy revival. The movie was rerun on Sleuth in 2008.

On October 25, 2011, NBC announced a pilot commitment for a updated series written by Alex Cary.