Eddie James "Son" House, Jr. was born in Mississippi in 1902, about two miles from the home of the Delta Blues, Clarksdale. At the age of fifteen Son House was to be found preaching sermons and was soon to become a young Baptist preacher. A self taught guitarist, Son House didn't take up the guitar until 1927 or 1928 after he was inspired by the slide guitar work of Willie Wilson. Son served time in Parchman State Farm, in Parchman, MS c1928-9. The "devil's music" was preached against by the Baptist Church, so it must have been difficult for Son to break away from his ministry to join up with the local bluesmen such as Willie Brown and Charlie Patton. He played with them or solo at jukes, parties, and plantations around the Robinsonville area of Mississippi north to Memphis through 1942. In 1943 he moved to Rochester, N.Y. to work for the New York Central Railroad. He worked outside of music for sixteen years from 1948 to 1964.

Son House recorded both for Paramount and the Library of Congress in the '30s and '40s, mainly for field recording units. Son's first recording session for Paramount in 1930 produced masterpieces considered to be at the summit of country blues recordings.

During the "rediscovery" period of blues in the early/mid 1960's he could be found playing the folk and blues festivals, working Washington, Philadelphia, and Newport amongst others. From this period on he started recording and touring again. Covering the Montreux Jazz Festival, and extensive recording in England (with Stephan Grossman), working college and club dates.

From the early 70's onwards, Son was plagued by ill health, playing infrequently and living outside the music genre he mastered and made his own. Despite all this, he still managed five wives before his death in 1988.